Mixed Mode Chromatography Resin Market - Industry Analysis, Market Size, Share, Trends, Application Analysis, Growth And Forecast 2022 - 2027

Report Code: CMR 35652 Report Format: PDF + Excel

Mixed Mode Chromatography Resin Market Overview

The Mixed Mode Chromatography Resin Market is estimated to grow at a CAGR of 6.4% during 2022-2027 and is forecasted to be valued at USD$142 million in 2027. Mixed Mode Chromatography utilizes two interaction principles in Chromatography. These interactions depend on the resins used with the most common ones being Ion Exchange-Hydrophobic interactions and Hydroxyapatite interactions. Mixed Mode Chromatography is based on media supports that are put into operation with ligands that enable multiple modes of interaction. Mixed Mode Chromatography is used in a variety of applications such as Antibodies production of both monoclonal antibodies and polyclonal antibodies, Non-antibody Proteins, Anti-drug conjugate, and so on. The report coverage includes various segmentations in the Mixed Mode Chromatography Resin Market along with Market Drivers and Challenges.

COVID-19 Impact

Many Industries and businesses suffered a loss due to the COVID-19 Pandemic as lockdowns were implemented and the supply chains were disrupted. However, the Mixed Mode Chromatography Resin Market had observed an increase in demand due to the Pandemic. This is because one of the primary applications of Mixed Mode Chromatography resin is Antibodies production. This is used by pharmaceutical companies to make drugs to combat and alleviate the effects of people suffering from the symptoms of COVID-19 and other illnesses in general. According to the European Federation of Pharmaceutical Industries and Associations (EFPIA), the Pharmaceutical Industry in North America saw a growth of 3.3% in 2020 while Europe saw a growth of 3.9%. While most markets saw a decline, the demand for the Pharmaceutical Industry, and by that sentiment, the Mixed Mode Chromatography Resin Industry, pushed for their growth. The market is expected to grow during the forecast period of 2022-2027.

Mixed Mode Chromatography Resin Market Report Coverage

The report: “Mixed Mode Chromatography Resin Market – Forecast (2022-2027)”, by IndustryARC, covers an in-depth analysis of the following segments of the Mixed Mode Chromatography Resin Market.

By Type: Ion Exchange-Hydrophobic, Hydroxyapatite, Others.
By Application: Antibodies Production, Non-antibody Proteins, Antibody-drug conjugate, Vaccine Production, Separation of Molecular Weight Impurities.
By Geography: North America (USA, Canada, and Mexico), Europe (UK, Germany, France, Italy, Netherlands, Spain, Russia, Belgium, and Rest of Europe), Asia-Pacific (China, Japan, India, South Korea, Australia and New Zealand, Indonesia, Taiwan, Malaysia, and Rest of APAC), South America (Brazil, Argentina, Colombia, Chile, and Rest of South America), Rest of the World (Middle East, and Africa). 

Key Takeaways

  • North America dominates the Mixed Mode Chromatography Resin Market in the geography segment.
  • Mixed Mode Chromatography Resins are most commonly used in the application of antibodies production, Vaccine Production, and Antibody-drug Conjugate.
  • Ion Exchange-Hydrophobic Interactions are the most common form of Mixed Mode Chromatography Interaction which are used to separate and purify protein molecules based on hydrophobicity.
  • The demand for vaccines during the COVID-19 Pandemic has proven to be a powerful driver for the Mixed Mode Chromatography Resin Market.

Figure: North America Mixed Mode Chromatography Resin Market 2021-2027 (USD $ Million)

 

                                                     

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Mixed Mode Chromatography Resin Market Analysis – By Type

Ion Exchange-Hydrophobic holds the largest share of 48% in the Types segment in 2021. Ion Exchange-Hydrophobic interaction is one of the strongest techniques when it comes to Mixed Mode Chromatography. Ion Exchange-Hydrophobic Interactions separate and purify protein molecules on basis of their hydrophobicity. This form of Mixed Mode Chromatography preserves the biological activity of the protein and also effectively removes impurities. Hydroxyapatite Interactions is another form of Mixed Mode Chromatography Interaction that is popular for biomolecule separation. Hydroxyapatite Interactions are excellent for removing aggregates from monoclonal antibodies. There are other types of Mixed Mode Chromatography as well however the most popular Interactions are Ion Exchange-Hydrophobic Interaction and Hydroxyapatite Interactions.

Mixed Mode Chromatography Resin Market Analysis – By Application

Antibodies Production holds the largest share by 40% in the Application segment in the year 2021. Mixed Mode Chromatography is most commonly used in the production of monoclonal and polyclonal antibodies. In monoclonal antibodies production, Mixed Mode Chromatography resin is very effective in removing aggregates, which are process and product-related impurities, under typical conditions. Another application of Mixed Mode Chromatography resin is in the production of vaccines. This has become extremely significant in recent times as the demand and production of COVID-19 vaccines have skyrocketed. According to the University of Oxford, as of October 2021, 6.84 billion doses of COVID-19 vaccines have been administered globally with 48.5% of the world population having been partially vaccinated with at least one dose. Vaccine production has proven to be a massive driver for the Mixed Mode Chromatography Resin Market.

Mixed Mode Chromatography Resin Market Analysis – By Geography

North America holds the largest segment of 43% in the geography segment of Mixed Mode Chromatography Resins Market in 2021. North America is at the forefront of Research and Development when it comes to pharmaceutical technology and is the world leader in the pharmaceutical business. According to the European Federation of Pharmaceutical Industries and Associations (EFPIA), the United States of America (USA) accounted for 49% of the global pharmaceutical sales in 2020 and also invested USD $64,357 million in Research and Development (R&D) in the Pharmaceutical Industry in 2019. The United States (USA) alone holds the largest share in terms of sales in the Pharmaceutical Industry, which is about 63.7% in 2020. The Mixed Mode Chromatography Resin Market is driven primarily by the Pharmaceutical Industry. North America dominates the market. 

Mixed Mode Chromatography Resin Market Drivers

The overwhelming demand for Vaccines against COVID-19:

One of the primary drivers for the Mixed Mode Chromatography Resin Market is the overwhelming demand for the COVID-19 virus. The need for vaccination is global and many governments are mandating vaccination for not only healthcare reasons but also as a means to reinstate pre-COVID-19 rules and regulations and recover the economy. According to the University of Oxford, as of October 2021, 6.84 billion doses of COVID-19 vaccines have been administered globally with 48.5% of the world population having been partially vaccinated with at least one dose. The United Nations Children’s Fund (UNICEF) has also stated that 19.5 billion doses have been secured globally and are the targeted dose for global vaccination.

Mixed Mode Chromatography Resin Market Challenges

Disadvantages of Mixed Mode Chromatography:

Even though Mixed Mode Chromatography proves to be incredibly effective and versatile, it still has some clear disadvantages when it comes to usage. One clear disadvantage is the low solubility of some compounds in high proportions of organic solvent. Ion Exchange-Hydrophobic Chromatography shows poor compatibility with Mass Spectrometry which is primarily due to the high concentration of buffering salts in the mobile phase. There is also the long column equilibration time responsible for long method development time. Such disadvantages prove to be a challenge for the Mixed Mode Chromatography Resin Market.

Mixed Mode Chromatography Resin Industry Outlook

Technology launches, acquisitions, and R&D activities are key strategies adopted by players in this market. Mixed Mode Chromatography Resin top 10 companies include:

  1. Bio-Rad Laboratories Inc.
  2. Tosoh Bioscience LLC
  3. Merck & Co.
  4. Life Technology Corporation
  5. Danaher Corporation
  6. Knauer GmBH
  7. SR Micro Inc.
  8. GE Healthcare Life Sciences
  9. Bio-Works Company Ltd.
  10. Kaneka Corporation

Recent Developments

In October 2021, Tosoh Bioscience LLC completed the acquisition of Semba Biosciences, a private company that is a leading innovator in Multi Column Chromatography (MMC) established in Wisconsin, United States.

In April 2020, Bio-Rad Laboratories acquired Celsee, Inc., a company that provides single-cell solutions. Celsee, Inc. provides a practical, scalable, and efficient approach to accurately analyze single cells.

Relevant Reports

Chromatography Resins Market - Forecast(2021 - 2026)

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Ion-Exchange Resins Market - Forecast(2021 - 2026)

Report Code: CMR 0422

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1. Mixed Mode Chromatography Resin Market- Market Overview
    1.1 Definitions and Scope
2. Mixed Mode Chromatography Resin Market - Executive Summary
    2.1 Key Trends by Type
    2.2 Key Trends by Application
    2.3 Key Trends by Geography
3. Mixed Mode Chromatography Resin Market – Comparative analysis
    3.1 Market Share Analysis- Major Companies
    3.2 Product Benchmarking- Major Companies
    3.3 Top 5 Financials Analysis
    3.4 Patent Analysis- Major Companies
    3.5 Pricing Analysis (ASPs will be provided)
4. Mixed Mode Chromatography Resin Market - Startup companies Scenario Premium Premium
    4.1 Major startup company analysis:
        4.1.1 Investment
        4.1.2 Revenue
        4.1.3 Product portfolio
        4.1.4 Venture Capital and Funding Scenario
5. Mixed Mode Chromatography Resin Market – Industry Market Entry Scenario Premium Premium
    5.1 Regulatory Framework Overview
    5.2 New Business and Ease of Doing Business Index
    5.3 Successful Venture Profiles
    5.4 Customer Analysis – Major companies
6. Mixed Mode Chromatography Resin Market - Market Forces
    6.1 Market Drivers
    6.2 Market Constraints
    6.3 Porters Five Force Model
        6.3.1 Bargaining Power of Suppliers
        6.3.2 Bargaining Powers of Buyers
        6.3.3 Threat of New Entrants
        6.3.4 Competitive Rivalry
        6.3.5 Threat of Substitutes
7. Mixed Mode Chromatography Resin Market – Strategic Analysis
    7.1 Value/Supply Chain Analysis
    7.2 Opportunity Analysis
    7.3 Product/Market Life Cycle
    7.4 Distributor Analysis – Major Companies
8. Mixed Mode Chromatography Resin Market – By Type (Market Size -$Million/Billion)
    8.1 Ion Exchange-Hydrophobic
    8.2 Hydroxyapatite
    8.3 Others
9. Mixed Mode Chromatography Resin Market – By Application (Market Size -$Million/Billion)
    9.1 Antibodies Production
    9.2 Non-Antibody Proteins
    9.3 Antibody-Drug Conjugate
    9.4 Vaccine Production
    9.5 Others
10. Mixed Mode Chromatography Resin Market - By Geography (Market Size -$Million/Billion)
    10.1 North America
        10.1.1 USA
        10.1.2 Canada
        10.1.3 Mexico
    10.2 Europe
        10.2.1 UK
        10.2.2 Germany
        10.2.3 France
        10.2.4 Italy
        10.2.5 Netherlands
        10.2.6 Spain
        10.2.7 Russia
        10.2.8 Belgium
        10.2.9 Rest of Europe
    10.3 Asia-Pacific
        10.3.1 China
        10.3.2 Japan
        10.3.3 India
        10.3.4 South Korea
        10.3.5 Australia and New Zealand
        10.3.6 Indonesia
        10.3.7 Taiwan
        10.3.8 Malaysia
        10.3.9 Rest of APAC
    10.4 South America
        10.4.1 Brazil
        10.4.2 Argentina
        10.4.3 Colombia
        10.4.4 Chile
        10.4.5 Rest of South America
    10.5 Rest of the World
        10.5.1 Middle East
            10.5.1.1 Saudi Arabia
            10.5.1.2 UAE
            10.5.1.3 Israel
            10.5.1.4 Rest of the Middle East
        10.5.2 Africa
            10.5.2.1 South Africa
            10.5.2.2 Nigeria
            10.5.2.3 Rest of Africa
11. Mixed Mode Chromatography Resin Market – Entropy
    11.1 New Product Launches
    11.2 M&As, Collaborations, JVs and Partnerships
12. Mixed Mode Chromatography Resin Market – Industry / Segment Competition landscape Premium Premium
    12.1 Company Benchmarking Matrix – Major Companies
    12.2 Market Share at Global Level - Major companies
    12.3 Market Share by Key Region - Major companies
    12.4 Market Share by Key Country - Major companies
    12.5 Market Share by Key Application - Major companies
    12.6 Market Share by Key Product Type/Product category - Major companies
13. Mixed Mode Chromatography Resin Market – Key Company List by Country Premium Premium
14. Mixed Mode Chromatography Resin Market Company Analysis - Business Overview, Product Portfolio, Financials, and Developments
    14.1 Company 1
    14.2 Company 2
    14.3 Company 3
    14.4 Company 4
    14.5 Company 5
    14.6 Company 6
    14.7 Company 7
    14.8 Company 8
    14.9 Company 9
    14.10 Company 10
"*Financials would be provided on a best-efforts basis for private companies"

LIST OF TABLES

1.Global Mixed Mode Chromatography Resin Market:Technique Estimate Trend Analysis Market 2019-2024 ($M)
1.1 Mixed Mode Chromatography Resin Demand By Technique Market 2019-2024 ($M) - Global Industry Research
1.1.1 Mixed Mode Chromatography Resin Market Estimate Forecast Market 2019-2024 ($M)
1.2 Ion Exchange-Hydrophobic Market 2019-2024 ($M) - Global Industry Research
1.2.1 Ion Exchange-Hydrophobic Resin Market Estimate Forecast Market 2019-2024 ($M)
1.3 Hydroxyapatite Market 2019-2024 ($M) - Global Industry Research
1.3.1 Hydroxyapatite Market Estimate Forecast Market 2019-2024 ($M)
2.Global Mixed Mode Chromatography Resin Market:End Use Estimate Trend Analysis Market 2019-2024 ($M)
2.1 Mixed Mode Chromatography Resin Demand By End Use Market 2019-2024 ($M) - Global Industry Research
3.Global Mixed Mode Chromatography Resin Market:Technique Estimate Trend Analysis Market 2019-2024 (Volume/Units)
3.1 Mixed Mode Chromatography Resin Demand By Technique Market 2019-2024 (Volume/Units) - Global Industry Research
3.1.1 Mixed Mode Chromatography Resin Market Estimate Forecast Market 2019-2024 (Volume/Units)
3.2 Ion Exchange-Hydrophobic Market 2019-2024 (Volume/Units) - Global Industry Research
3.2.1 Ion Exchange-Hydrophobic Resin Market Estimate Forecast Market 2019-2024 (Volume/Units)
3.3 Hydroxyapatite Market 2019-2024 (Volume/Units) - Global Industry Research
3.3.1 Hydroxyapatite Market Estimate Forecast Market 2019-2024 (Volume/Units)
4.Global Mixed Mode Chromatography Resin Market:End Use Estimate Trend Analysis Market 2019-2024 (Volume/Units)
4.1 Mixed Mode Chromatography Resin Demand By End Use Market 2019-2024 (Volume/Units) - Global Industry Research
5.North America Mixed Mode Chromatography Resin Market:Technique Estimate Trend Analysis Market 2019-2024 ($M)
5.1 Mixed Mode Chromatography Resin Demand By Technique Market 2019-2024 ($M) - Regional Industry Research
5.1.1 Mixed Mode Chromatography Resin Market Estimate Forecast Market 2019-2024 ($M)
5.2 Ion Exchange-Hydrophobic Market 2019-2024 ($M) - Regional Industry Research
5.2.1 Ion Exchange-Hydrophobic Resin Market Estimate Forecast Market 2019-2024 ($M)
5.3 Hydroxyapatite Market 2019-2024 ($M) - Regional Industry Research
5.3.1 Hydroxyapatite Market Estimate Forecast Market 2019-2024 ($M)
6.North America Mixed Mode Chromatography Resin Market:End Use Estimate Trend Analysis Market 2019-2024 ($M)
6.1 Mixed Mode Chromatography Resin Demand By End Use Market 2019-2024 ($M) - Regional Industry Research
7.South America Mixed Mode Chromatography Resin Market:Technique Estimate Trend Analysis Market 2019-2024 ($M)
7.1 Mixed Mode Chromatography Resin Demand By Technique Market 2019-2024 ($M) - Regional Industry Research
7.1.1 Mixed Mode Chromatography Resin Market Estimate Forecast Market 2019-2024 ($M)
7.2 Ion Exchange-Hydrophobic Market 2019-2024 ($M) - Regional Industry Research
7.2.1 Ion Exchange-Hydrophobic Resin Market Estimate Forecast Market 2019-2024 ($M)
7.3 Hydroxyapatite Market 2019-2024 ($M) - Regional Industry Research
7.3.1 Hydroxyapatite Market Estimate Forecast Market 2019-2024 ($M)
8.South America Mixed Mode Chromatography Resin Market:End Use Estimate Trend Analysis Market 2019-2024 ($M)
8.1 Mixed Mode Chromatography Resin Demand By End Use Market 2019-2024 ($M) - Regional Industry Research
9.Europe Mixed Mode Chromatography Resin Market:Technique Estimate Trend Analysis Market 2019-2024 ($M)
9.1 Mixed Mode Chromatography Resin Demand By Technique Market 2019-2024 ($M) - Regional Industry Research
9.1.1 Mixed Mode Chromatography Resin Market Estimate Forecast Market 2019-2024 ($M)
9.2 Ion Exchange-Hydrophobic Market 2019-2024 ($M) - Regional Industry Research
9.2.1 Ion Exchange-Hydrophobic Resin Market Estimate Forecast Market 2019-2024 ($M)
9.3 Hydroxyapatite Market 2019-2024 ($M) - Regional Industry Research
9.3.1 Hydroxyapatite Market Estimate Forecast Market 2019-2024 ($M)
10.Europe Mixed Mode Chromatography Resin Market:End Use Estimate Trend Analysis Market 2019-2024 ($M)
10.1 Mixed Mode Chromatography Resin Demand By End Use Market 2019-2024 ($M) - Regional Industry Research
11.APAC Mixed Mode Chromatography Resin Market:Technique Estimate Trend Analysis Market 2019-2024 ($M)
11.1 Mixed Mode Chromatography Resin Demand By Technique Market 2019-2024 ($M) - Regional Industry Research
11.1.1 Mixed Mode Chromatography Resin Market Estimate Forecast Market 2019-2024 ($M)
11.2 Ion Exchange-Hydrophobic Market 2019-2024 ($M) - Regional Industry Research
11.2.1 Ion Exchange-Hydrophobic Resin Market Estimate Forecast Market 2019-2024 ($M)
11.3 Hydroxyapatite Market 2019-2024 ($M) - Regional Industry Research
11.3.1 Hydroxyapatite Market Estimate Forecast Market 2019-2024 ($M)
12.APAC Mixed Mode Chromatography Resin Market:End Use Estimate Trend Analysis Market 2019-2024 ($M)
12.1 Mixed Mode Chromatography Resin Demand By End Use Market 2019-2024 ($M) - Regional Industry Research
13.MENA Mixed Mode Chromatography Resin Market:Technique Estimate Trend Analysis Market 2019-2024 ($M)
13.1 Mixed Mode Chromatography Resin Demand By Technique Market 2019-2024 ($M) - Regional Industry Research
13.1.1 Mixed Mode Chromatography Resin Market Estimate Forecast Market 2019-2024 ($M)
13.2 Ion Exchange-Hydrophobic Market 2019-2024 ($M) - Regional Industry Research
13.2.1 Ion Exchange-Hydrophobic Resin Market Estimate Forecast Market 2019-2024 ($M)
13.3 Hydroxyapatite Market 2019-2024 ($M) - Regional Industry Research
13.3.1 Hydroxyapatite Market Estimate Forecast Market 2019-2024 ($M)
14.MENA Mixed Mode Chromatography Resin Market:End Use Estimate Trend Analysis Market 2019-2024 ($M)
14.1 Mixed Mode Chromatography Resin Demand By End Use Market 2019-2024 ($M) - Regional Industry Research

LIST OF FIGURES

1.US Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
2.Canada Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
3.Mexico Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
4.Brazil Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
5.Argentina Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
6.Peru Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
7.Colombia Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
8.Chile Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
9.Rest of South America Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
10.UK Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
11.Germany Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
12.France Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
13.Italy Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
14.Spain Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
15.Rest of Europe Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
16.China Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
17.India Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
18.Japan Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
19.South Korea Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
20.South Africa Mixed Mode Chromatography Resin Market Revenue, 2019-2024 ($M)
21.North America Mixed Mode Chromatography Resin By Application
22.South America Mixed Mode Chromatography Resin By Application
23.Europe Mixed Mode Chromatography Resin By Application
24.APAC Mixed Mode Chromatography Resin By Application
25.MENA Mixed Mode Chromatography Resin By Application
26.Merck Kgaa, Sales /Revenue, 2015-2018 ($Mn/$Bn)
27.Bio-Rad Laboratories, Inc, Sales /Revenue, 2015-2018 ($Mn/$Bn)
28.Ge Healthcare, Sales /Revenue, 2015-2018 ($Mn/$Bn)
29.Puro-Lite Corporation, Sales /Revenue, 2015-2018 ($Mn/$Bn)
30.Tosoh Corporation, Sales /Revenue, 2015-2018 ($Mn/$Bn)
31.Danaher Corporation, Sales /Revenue, 2015-2018 ($Mn/$Bn)
32.Avantor Performance Material Inc, Sales /Revenue, 2015-2018 ($Mn/$Bn)