3D bioprinting or three-dimensional printing of organs, living cells, and other biomaterials is the newest trend to have disrupted the global 3D printing market. 3D Printing has witnessed prolific growth in the last decade owing to several industries openly adopting the technology and experimenting with it. The healthcare industry has followed suit and developed the 3D Bioprinting Market, which is consistently undergoing a variety of experimentation and research to manufacture organs with vascular accuracy. In breakthrough research conducted by bioengineers at University of Washington and Rice University, a solution was invented to prevent the printing of inaccurate and dysfunctional complex vascular networks that were initially negatively impacting the 3D bioprinting market growth. The research published in May 2019 in the journal titled Science stated the development of a lung’s hydrogel model that for the first time has a proper vascular network depicting blood vessels and bile ducts which are necessarily the most important parts of a living body. With this development, which includes printing of organ lookalikes, key market players will now shift their primary focus towards the challenge of making these printed organs perfectly emulate the in vivo functionality. This will be extremely beneficial for patients around the world who often suffer from organ failure and have to rely on donor facilities to get a transplant. Efficient and accurate 3D bioprinting will make organ transplants much easier and frequent, thus providing impetus to the global healthcare industry. During the forecast period of 2019-2025, the 3D bioprinting market will witness considerable growth an outstanding CAGR of 19.83%. In 2018, the market earned a revenue of $963.76m.
Growth Drivers of the 3D Bioprinting Market
· A Perfect Solution to Skin Scarring
Aesthetic appearance is quite crucial for humans while being extremely susceptible to adverse modifications at the same time. According to the National Center for Biotechnology Information, approximately 100 million people every year acquire scars in a body part. The causes for acquiring these scars are many with primary factors including accident injuries and post-surgical scars. Several psychological and aesthetic consequences are attached to stars, with increased financial investment in the removal and camouflaging. A growing interest by the dermatology field and skincare industry has been generated for 3D bioprinting market which offers revolutionary solutions for scarring. This technology provides customizable skin grafts for different patients, which does not involve any side effects. Several cosmetic companies picking up on this trend have already commenced projects, thus positively impacting the 3D bioprinting market. A partnership occurred between L’Oreal’s USA technology incubator and Organovo in May 2015 to work together to develop skin tissue through 3D bioprinting technology. Another significant partnership took place between Procter & Gamble with Singapore’s Agency for Science for 3D printing living tissues. Proctor & Gamble have invested approximately SDG $60m in this collaboration to instigate the growth of the 3D bioprinting market. The healthcare industry is, therefore, the leading application of the market, and this segment will grow with a CAGR of 21.03%, during the forecast period of 2019-2025.
· A Replacement for Animal Testing
Animal testing forms an imperative step for many industries to run their prototypes undertrials before being released into the public. Cosmetics and pharmaceutical industries are majorly responsible for cruelty on animals in the form of product testing. With growing awareness and compassion amongst people for saving animals, there is worldwide outrage for animal testing to either be banned for replaced with a more human version of testing. According to 2017 statistical figures released by the U.S. Department of Agriculture, Animal, and Plant Health Inspection Service’s Annual Report Animal Usage by Fiscal Year, 1 million animals (excluding mice and rats) have been held captive all across the U.S. for experiments and testing. Moreover, 100 million rats and mice have also been kept in captivity across the country. These statistics are alarming and point out towards the distressing number of animal tests being carried out in the name of scientific experiments. According to a poll conducted by Pew Research Center, 52% of American adults vehemently oppose animals being used in scientific research. Furthermore, consistent scientific research has proven the lack of relatability between in vivo environments of animals and humans. Animal experimentation provides little or zeroes analysis of how a particular product would impact human skin or human health. This has acted as a significant growth driver for the 3D bioprinting market as the technology allows fast and accurate printing of living cells and tissues. Drugs, cosmetics, and therapies that were being tested on animals are now reliant on cell culture, thus benefitting both animal lives and human health.
North America Leading in Growth of the Global 3D Bioprinting Market
North America has emerged as the geographical leader of the 3D bioprinting market with a 41% share out of the total revenue earned by the market in 2018. According to UNOS Data and Transplant Statistics, once in every ten minutes, a person gets added in the American transplant list for organ replacement. Moreover, 20 people die every year without getting a transplant, thus even further necessitating the importance of organ transplant. These statistics are reflective of the growing demand for organs transplant in North America, which houses two of the most advanced countries based on healthcare facilities. This is the reason why the 3D bioprinting market has gained maximum growth in this region for its promising technology to make organ replacement faster and frequent. Organovo, one of the key players of the 3D bioprinting market partnered with Samsara Science in 2018 to collaborate with The Advanced Regenerative Manufacturing Institute (ARMI) which receives considerable investment from universities and non-profitable organizations to develop scalable technologies for scientifically engineered organs. For this project, the federal government invested $80m, which will be used to support the development of printed organs and tissues.
3D Bioprinting Market: Collaborations From Key Players
The 3D bioprinting market is undergoing a transition stage where complex research is being performed in biotechnology institutes to instigate market growth. Key market players of the market are directly responsible for the investment going in these researchers and their subsequent commencement and implementation. Some of the key market players operating in the 3D bioprinting market are 3D Biotek, Allevi, Inc., Regenovo Biotechnology Co., Ltd., Poietis, Organovo, Nano3D Biosciences, Inc., EnvisionTEC, Stratasys, Ltd., regenHU Ltd., and Cyfuse Biomedical K.K.
Cyfuse Biomedical K.K. is a Japanese company founded by a professor at Saga University where routine researches and tests pertaining to biotechnology are regularly performed. Some of the specialties of the company include the development of regenerative medicine, biomedical engineering, and now, 3D bioprinting. In May 2019, a collaboration was signed amongst Keio University, Cyfuse Biomedical K.K., Kyoto Prefectural University of Medicine, Saga University and Hospital, and Kyushu Medical Center to upscale the 3D bioprinting technology. To date, bioprinting has only been performed and tested in small animal models. However, with this collaboration, its services will be extended to humans as well in the next two decades. One of the first developments to have stemmed from this collaboration is a study that was performed on pigs and resulted in prolonged survival of vascular grafts. According to the associates involved in the research, this will be imperative in developing pre-clinical stage strategies for 3D bioprinting for the regeneration of human cells.
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