The rapid evolution of (NGS) next-generation sequencing technologies is paving a paradigm shift in the modern era of medical genetics. DNA polymerase is the sole foundation and widespread in this innovation of the biomedical field. Owing to this revolution, at present, life science research is experiencing a large scale of whole genome sequencing. Furthermore, clinical applications of NGS is thriving with advancements in the DNA polymerase market and swiftly progressing in the forthcoming future. This progress is leading to the rapid discovery of new genes connected to human inherited disorders. As a result, diagnostics of human hereditary disorders, infectious diseases, and immune disorders are gaining demand in the clinical laboratories. With all these advancements in the next-generation sequencing, the global DNA polymerase market demand has attained a value of $300 million in 2018. Furthermore, the opportunities in the market are projected to grow at a CAGR of 6.5% during the forecast period 2019-2025.

Forensics Industry Surging with Research Activities in Polymerase Chain Reaction of the DNA Polymerase Market

Around the world, national bureaus of investigation across several countries seek to enhance national security and public safety and through advanced DNA technology. The advent of the latest DNA sequencing technologies paved the way to a plethora of real-time Polymerase Chain Reaction (PCR) applications in genetic testing, forensic sciences, and diagnostics. The enzyme replication of Prokaryotic DNA Polymerase and Eukaryotic DNA polymerase is highly beneficial in PCR. PCR technique makes use of specific oligonucleotides in DNA polymerase often used in clinical laboratories in forensic science. Oligonucleotides contain 2'-deoxyribonucleotides (oligodeoxyribonucleotides), which are a part of DNA used in the PCR and also find varied applications in genetic testing and forensics. False-negative results and low-sensitivity are the major problems addressed by PCR-based forensic tests. In this technique, the high precision of the amount of definite nucleic acids in a sample is identified. This enables the forensics to analyze the owner of a DNA sample left in a crime scene. In the forensics industry, research activities related to DNA sequencing in PCR are skyrocketing. For instance, in 2017, Nagoya University of Japan carried out research activity in modern DNA profiling techniques which involve PCR. This research inferred that forensic scientists could be able to recover human DNA from mosquitoes up to 2 days after feeding. Also, they can match the DNA collected from human blood that is taken from mosquito’s stomach. This helps the police to identify the persons who are available at the crime scene. This kind of activities is further supported by the national governments of several countries such as the U.S. and Germany to proliferate the safety of citizens.

Biotechnology Companies Benefiting with Genome Editing in the DNA Polymerase Market

According to the United Nations, the world population is anticipated to reach 8.6 billion in 2030. With around 83 million people added every year to the world population, the global necessities to live, grow, and manufacture effectively and efficiently are rising. Biotechnology plays a significant role to meet these daunting demands of environmental, health, economic, and social factors. To align with these demands, countries are placing robust and diverse biotech ecosystems which are thriving with innovations and research activities. Biotechnology scientists are exploring a myriad of potential activities in human, plant, and animal genome editing. DNA polymerase is a ubiquitous class of enzyme in the biotechnology. In genome editing, it restores the integrity of DNA strands and repairs those which are damaged from constant exposure to environmental factors. Polymerase activities are harnessed for addressing labeling, detection, and amplification of DNA sequences.

The adoption of crop technology is thriving with DNA sequencing. Biotech crops have increased ~112-fold. For instance, in 2017, as a part of the 22nd year of global commercialization of biotech crops, 24 countries planted about 189.8 million hectares of biotech crops with the U.S., Brazil, Argentina, Canada, and India as the top countries and with an increase of 3% from the preceding year. Furthermore, there is a huge demand influx experienced from the European countries such as Germany and Spain; the latter accounted for about 95% of the biotech crops grew in entire Europe, as of 2017. With this predominant growth in the industry, the biotechnology companies, along with farmers and researchers, are heightening interest in the sustainable production of health and nutritional plants. This constitutes a significant growth in the DNA polymerase market of the plant genome editing. With these vast growth prospects, the biotechnology companies are further thriving with innovations and research activities in the global DNA polymerase market. As a result, biotechnology companies are accelerating with a CAGR of 8% in the global DNA polymerase market.

North America Experiencing Huge Growth Prospects in the End-User Industries of the DNA Polymerase Market

North America DNA polymerase market was leading in the global marketplace and accounted for a 40% revenue share in 2018. The region is a leader in growing biotech crops accounting for 46.4% in the global market, with the U.S being top producer, as of 2017. Furthermore, the U.S is experiencing humongous opportunities in R&D activities of DNA polymerase in diagnostics and therapeutic applications. According to the International Federation of Pharmaceutical Manufacturers and Associations, in 2015, the U.S occupied a 40.3% share in the global pharmaceutical market, and the share will increase to 41% in 2020. Besides, Canada’s healthcare, pharmaceutical, and biotechnology industries are very robust and game-changers in the global marketplace. Constant R&D activities in these industries are triggering the DNA polymerase market growth. Along with that, the discovery of specialized DNA polymerases that can replicate damaged DNA, which is targeted in anticancer therapies is rising in Canada’s DNA polymerase market. Mismatches in the base pairing of nucleotides are resolved with the help of DNA polymerase by engaging in DNA repair and DNA damage tolerance. Cancer is the leading cause of death in Canada, and on an average, about 221 Canadians died from cancer every day, in 2017. With all these growth prospects in North America, the DNA polymerase market demand is surging in this region.

Key Players in the Global DNA Polymerase Market

The core companies operating with a major share in the global DNA polymerase industry are Thermo Fisher Scientific Inc., Merck KGaA, Qiagen N.V., Takara Bio Inc., New England Biolabs, Inc., F. Hoffmann-La Roche AG, Genescript, Illumina Inc., Agilent Technologies Inc., and Bioline & Promega Corporation. Numerous collaborative research projects with research institutes or other companies are thriving in this market.

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