Nucleic Acid Aptamers Market Size is estimated to reach $412.3 million by 2027 and it is poised to grow at a CAGR of 17.4% over the forecast period of 2022-2027. Aptamers are small single-stranded oligonucleotides (DNAs or RNAs) with comparatively low molecular weight, ranging from 5-40 kDa. Nucleic acid aptamer groups have more flexibility and minor complexity and immunogenicity allowing them to attach to interior non-accessible epitopes that cannot be easily targeted by antibodies. Aptamer sciences have been applied in various life sciences fields as new drugs, nanoparticle agents for diagnostic and bio-imaging, drug-delivery agents, analytical reagents, food, and hazard detection applications. The nucleic acid aptamers market in the U.S. is majorly driven by the aptamer companies in the U.S. who are constantly evolving the sphere of research to curate products and services which serve a wider purpose, while various clinical trials are being performed to expand the application. 

Nucleic Acid Aptamers Market Drivers

An Increasing Case Load of Bacterial-Resistant Diseases Has Propelled the Market Usage of Nucleic Acid Aptamers.

Aptamers, other than recognized forms of treatment, are highly regarded as antimicrobial agents. Further, biofilm-forming bacteria, which result in chronic infections, have developed increased resistance against antibiotic treatments and host defense systems. As per CDC, in 2019 around 2.8 million anti-microbial resistance infections took place in the U.S. while claiming nearly 35,000 lives. The technology is highly regarded in fatal infections due to the presence of anti-biofilm activity.

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Peculiar Advantages of Aptamers Over Antibodies Preside to An Increasing Use of The Former In Multiple Applications.

Antibodies have presented a strong challenge for targeting small molecules, however, aptamers have conducted effectivity in targeting small molecules. Owing to this they can bind to small molecules and dyes and thus be easily used in conventional diagnostic kits, extending their use to point-of-care diagnostics. Furthermore, aptamers are successful to bind with larger molecules as well. Nearly 98% of all the molecules tend to be proteins, which intrinsically are larger than the rest.

Product Launch and Collaboration

In September 2022, Cage Bio - A biotech company, and TAGCyx Biotechnology Company announced the execution of a license-based agreement for the development of TAGX-0003. TAGX-0003 is is a DNA aptamer possessing potent interferon-gamma (IFNg) antagonistic activity developed by TAGCyx. 

In June 2022, Waseda University researchers developed RaptGen, a variational autoencoder that efficiently discovers new aptamers not included in the input SELEX dataset.

The Major Players in The Market Include

The Major Players in the Nucleic Acid Aptamers Market include Aptamer Group, Raptamer Discovery Group, Soma-Logic, Aptamer Sciences, Aptagen, Maravai Lifesciences, Kaneka Corporation, Neo Ventures Biotechnology, Aptus Biochem, and Base Pair Technologies.

Recent advancements in the generation, purification, and drug delivery for killing target cells have attracted the attention of many researchers towards aptamers owing to the competitive advantages associated with them. Owing to the following reasons, the nucleic acid aptamers industry will offer lucrative opportunities to marketers.

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