3D Cell Culture Market Overview
The 3D cell culture market size is estimated to reach $1.9 billion by 2027 and is poised to grow at a CAGR of 11.1% over the forecast period of 2022-2027. In the following environment of culture, the cells are allowed to grow and interact with each other in the surrounding extracellular framework. The following technology is different from the former, as in that-2D cultures were grown on the flat monolayer of a plate. Moreover, the 3D cell cultures can be grown with or without a supporting scaffold. The 3D cell cultures were of predominant use in vaccine development, which helped dearly in the pandemic-driven years. The study also found that techniques like organoids and spheroid cultures have been shown to replicate systems of viral infection more accurately. Matrigel has been commonly used as a cell culture matrix, and it allows as the growth factors for cytokine within the cell. Similarly, the hydrogels have been a well-defined water-swollen network of polymers. The physiological environment in classical 2D cultures is less persistent than 3D cultures of human mesenchymal stem cells. The use of 3D cell cultures in treating cancer and other diseases as an alternative to the traditional approaches. Additionally, the growth of the geriatric population with the rising ailments are some of the factors driving the 3D cell culture industry forward in the projected period of 2022-2027.
The report: “3D Cell Culture Market Forecast (2022-2027)", by Industry ARC covers an in-depth analysis of the following segments of the 3D Cell Culture Market.
- Geographically, North America’s 3D Cell Culture held a dominant market share in the year 2021. It is owing to the development of various 3D cell culture bases, moreover, the region has favorable policies which allow the researchers to identify new and better products. However, Asia-Pacific is set to offer lucrative growth opportunities to marketers. It is owing to the upcoming CROs coming up in the region and other technological innovations which will shape the demand.
- An increase in the cases of cancer globally and the alternate ways to find drugs to address are some of the factors driving the market. However, the high costs and difficulty to replicate cells in microenvironments are some of the challenges faced by the market.
- A detailed analysis of strengths, weaknesses, opportunities, and threats will be provided in the 3D Cell Culture market report.
3D Cell Culture Market Segmentation Analysis- By Types
The 3D cell culture market based on type can be further segmented into Scaffold Based and Scaffold- Free, Bioreactors, and Microfluidic Organ on a Chip Models. The scaffold-based segment held a dominant market share in 2021. The cells can quickly impart growth. Moreover, scaffold-based applications allow ease in imaging, and the assay protocol is simple. Additionally, one can modify the mechanical and biochemical properties as per their ease.
However, the microfluidic organ on a chip model is estimated to be the fastest-growing, with a CAGR of 11.7% over the forecast period of 2022-2027. It is owing to its properties that allow for future complex advents and help solve common aspects of human physiology, pathology, and even drug responses. Additionally, academic stakeholders are actively using the following type as it allows to address oxygen delivery, throughput, and assay multiplexing. Organ on a chip shows prospects in-vivo studies to depict the real life of a human. Vital organs such as the brain, lung, liver, intestine, kidney, and heart all can run on the following prospects. It would be vital for people who are undergoing various types of treatments or are on life-support. For example, around 500,000 open-heart surgeries are performed in the U.S, and the chances of surviving owing to complexities go binomial. Hence, the following technology can aid in sustenance.
3D Cell Culture Market Segmentation Analysis- By End Users
The 3D cell culture market based on the end-users can be further segmented into Biotechnology and Pharmaceutical Companies, Academia and Research Centers, Contract Research Organizations, and Others. Pharmaceutical and Biotechnology held a dominant market share in the year 2021. For example, major drug manufacturers developed vaccines and supported other stem cell therapy resources to a better life in 2021 and in the preceding year. Moreover, governmental agencies supported their growth. Moreover, the cases of serious illnesses have been on the rise, and private players are readily seeking grant helps to allow better research. The following have helped for the sizable share.
However, CROs or Contract research organization is estimated to be the fastest-growing, with a CAGR of 11.9% over the forecast period of 2022-2027. It is owing to the major benefits it offers over the traditional ways. For example, by outsourcing activities pertaining to research and development, the patent holder needs not to spend excessive time and costs in selecting the right set of individuals, and hence, saves multitudes of costs. Additionally, giants such as Incyte used approximately $2.216 billion on R&D activities, and out of which the predominant share was by clinical research conducted on off-site service locations. The following trends are not just limited to one, but multiple companies are following the same trend which will allow the growth.
3D Cell Culture Market Segmentation Analysis- By Geography
The 3D culture Market based on Geography can be further segmented into North America, Europe, Asia-Pacific, South America, and the Rest of the World. North America’s 3D cell culture held a dominant market share of 40% as compared to the other regions. It is owing to the growing need in various applications. The prevalence of cancer has been on the rise or has been constant over the last years. More so, 1.8 million people develop cancer in the US every year, and of which a third of the entirety succumb to the disease. Stem cell therapy has been gaining prominence to treat cancer, and the use of 3D cell culture has allowed the market to hold a sizable portion.
However, Asia-Pacific is set to offer lucrative growth opportunities to marketers in the projected period of 2022-2027. It is owing to the rising influx of FDI seen in the biotechnology and pharma sector, as the regions offer benefits of economies of scale. Additionally, regions such as India is now allocating an increased share of the budget for healthcare developments, such as in the year 2021, a 137% increment was noted. Similar trends across the countries like Korea and Japan will help the market to grow multifold.
3D Cell Culture Market Drivers
Allowing more accurate results and efficacy in drug discovery has acted as a key driver.
Each patient suffering from cancer exhibits different cell growth, and their nature is also different, which makes it difficult for the researchers to determine the appropriate treatment. However, 3D cell cultures now allow personalized treatment. The blood which would be collected from the afflicted patient will allow the researchers to study the nature and develop and test drugs. Moreover, heterogeneity exists within the same tumor. The cancer cells are made up of various phenotypes- each exhibiting a unique behavior. Furthermore, not all cancer patients would benefit from chemotherapy as there would be certain phenotypes resistant to the same. By using 3D cell cultures, the same can be evaluated, and better treatments can be rolled out. For example, there are around 230,000 new cases pertaining to cancer within Canada. Lastly, as per further analysis, nearly 1 in every 2 Canadians are expected to develop cancer in their lifetime.
The demand to find alternatives to animal testing has augmented the growth of the market.
Predominantly, drugs that are to be used on humans are first tested on the animal. More so, lab rats exhibit around 85% same genes when compared to humans. However, the remaining 15% difference has resulted in late side-effects and fatality. Moreover, the animals need to be fed, kept with care, and hence, operational costs pertaining to those factors have started demotivating the market researchers. More so, people are gaining more conscience for animal cruelty, which also includes testing animals for various experiments. Hence, the growth of psychological aspects along with operational hazards has allowed for the growth of the market. For example, if generic toxicity pertaining to unscheduled DNA synthesis takes place, the cost for the animal test can go as high as $32,000. However, an in-vitro study can only cost $11,000. The following differences are propelling the marketers to adopt 3D cell culture.
3D Cell Culture Market Challenges
The high costs and difficulty to replicate cells in microenvironments are some of the challenges faced by the market.
The costs kept for the 3D cell cultures are often placed high, which in turn de-motivates the end-users to purchase the said system. Moreover, high costs pertaining to assay validation, correlation to historical 2D culture results, analytical techniques are some of the valid issues being felt. The coting which is present on the 3D models prevent the reagents to penetrate the center of the spheroid. Additionally, inaccurate results were created when assays used were not upto the mark. The following challenge would discourage the new end-users and stop the market penetration.
3D Cell Culture Market Competitive Landscape
Product launches, mergers and acquisitions, joint ventures, and geographical expansions are key strategies adopted by players in the 3D Cell Cultures Market. The top 10- 3D Cell Culture Market companies are-
- Thermo Fisher Scientific,
- Corning Incorporated,
- Merck KgaA,
- Lonza Group,
- 3D Biotek LLC,
- Emulate, Inc.,
- CN Bio Innovations Limited,
- Hamilton Company
- Insphero AG
- In May 2021, Corning launched HepGo TM, which is an assay-ready 3D liver spheroid kit. It is an addition to their already robust product portfolio and allows for better recapitulate in-vivo behavior, which delivers improved results for drug safety and efficacy screening. The kit would also allow the end-users to use it for various applications, such as hepatoxicity assay. The 3D liver kit would also allow liver toxicity solution and reduce the time-consuming procedures.
- In July 2021, Amerigo Scientific launched its 3D cell cultures bioreactor, which would allow for rapid cell colonization in an in-vitro study. Moreover, it would also allow for the development of an in-vivo like microenvironment. It allows for greater predictivity and enhanced efficiency of toxicity. The culture would also allow for modulation of gene expression, which will help in antigenic profiling whereby mimicking an in-vivo environment.
Cell Culture Market- Forecast (2022-2027)
Report Code- HCR 0090
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Report Code- HCR 1218
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