Anti-Adhesion Products Market - Forecast(2024 - 2030)

Report Code: HCR 0851 Report Format: PDF + Excel
Anti-Adhesion Products Market Overview

Anti-Adhesion Products Market size is estimated to reach $873.4 million by 2027, growing at a CAGR of 5.4% during the forecast period 2022-2027. Adhesions repeatedly happen subsequent to abdominal surgery. Numerous anti-adhesion products have been utilized in clinics. Pilot investigations evaluating the efficiency of a sprayable polyethylene glycol (PEG) barrier in the avoidance of de novo adhesions subsequent to gynaecological laparoscopic surgery have been conducted. Currently, an anti-adhesion gel barrier, hyaluronic acid gel, has been brought in. Hyaluronic acid is a natural lubricant in the joints, which can add to adhesion avoidance by mechanical segregation of peritoneal surfaces. Oxidized regenerated cellulose (ORC), is one of the most chosen products for avoiding adhesion in clinical applications. Fibrinogen and fibrin are anti-adhesive for keratinocytes. Evicel, developed by Johnson & Johnson, is a kind of "Fibrin Glue", a two constituent product prepared from naturally happening molecules derived from human blood. It is principally utilized to regulate bleeding at the time of surgery.

The surging awareness regarding the medical indications of adhesions among both patients and doctors is set to drive the Anti-Adhesion Products Market. The soaring development of the volume of surgical procedures and demographic trends together with the introduction of anti-adhesive products including hyaluronic acid is set to propel the growth of the Anti-Adhesion Products Market during the forecast period 2022-2027. This represents the Anti-Adhesion Products Industry Outlook.

Report Coverage

The report: Anti-Adhesion Products Market Forecast (2022-2027)”, by Industry ARC, covers an in-depth analysis of the following segments of the Anti-Adhesion Products Market.

By Type Of Surgery: Abdominal Surgery, Gynaecological Surgery, Cardiovascular Surgery, Orthopaedic Surgery, Others.
By Geography: North America (U.S, Canada and Mexico), Europe (Germany, France, UK, Italy, Spain, Russia and Rest of Europe), Asia-Pacific (China, Japan, South Korea, India, Australia & New Zealand, and Rest of Asia-Pacific), South America (Brazil, Argentina, Chile, Colombia, Rest of South America), and Rest Of The World (Middle East, Africa).

Key Takeaways

  • Geographically, North America Anti-Adhesion Products Market accounted for the highest revenue share in 2021 and it is poised to dominate the market over the period 2022-2027 owing to the soaring count of products endorsed by the U.S. Food And Drug Administration (FDA) including hyaluronic acid in the North American region.
  • Anti-Adhesion Products Market growth is being driven by the increasing predominance of postsurgical adhesive ailments, google patents on hyaluronic acid for avoiding post surgical adhesions and their clinical complications and unwanted patient consequences. However, Seprafilm is infrequently utilized in laparoscopic surgery owing to its inclination to break apart when it is introduced into the abdominal cavity by way of a trocar, leading to a soaring placement failure rate and this is one of the major factors hampering the growth of Anti-Adhesion Products Market. 
  • Anti-Adhesion Products Market Detailed Analysis on the Strength, Weakness, and Opportunities of the prominent players operating in the market will be provided in the Anti-Adhesion Products Market report.

Anti-Adhesion Products Market: Market Share (%) by Region, 2021

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Anti-Adhesion Products Market Segment Analysis – By Product Type:

The Anti-Adhesion Products Market based on product type can be further segmented into ADEPT, SEPRAFILM, INTERCEED and SURGIWRAP. The SEPRAFILM Segment held the largest market share in 2021. This growth is owing to the surging application of Seprafilm as an adjunct in abdominal and pelvic surgery for decreasing the incidence, extent and severity of postoperative adhesions at the site of placement, and to decrease adhesive small bowel impediment when established in the abdomen. Hyaluronic acid is utilized as an anti-adhesive barrier. The comprehensive assessment of SEPRAFILM in comparison with other adhesion barriers is further propelling the growth of the SEPRAFILM segment.

Furthermore, the ADEPT segment is estimated to grow with the fastest CAGR of 6.5% during the forecast period 2022-2027 owing to the proliferating application of ADEPT indicated to be utilized in gynaecological laparoscopic surgery of the abdominal-pelvic cavity in mature grown-ups apart from hyaluronic acid being used as an anti-adhesive barrier.

Anti-Adhesion Products Market Segment Analysis – By Type Of Surgery:

The Anti-Adhesion Products Market based on the type of surgery can be further segmented into Abdominal Surgery, Gynaecological Surgery, Cardiovascular Surgery, Orthopaedic Surgery, and Others. The Abdominal Surgery Segment held the largest market share in 2021. This growth is owing to the frequent happening of adhesions post abdominal surgery. Topical application of solutions including hyaluronic acid has been demonstrated to decrease adhesions post abdominal and orthopaedic surgery. The proliferating application of anti-adhesive products like SEPRAFILM as an adjunct in abdominal surgery is further propelling the growth of this segment.

Furthermore, the Gynaecological Surgery segment is estimated to grow with the fastest CAGR of 6.3% during the forecast period 2022-2027 owing to the surging application of antiadhesive products like ADEPT designed for application as an intraperitoneal instilled for the decrease of adhesions succeeding gynaecological laparoscopic surgery and needs to be utilized as the irrigant at the time of the course of that surgery apart from hyaluronic acid being utilized as an anti-adhesive barrier.

Anti-Adhesion Products Market Segment Analysis – By Geography:

The Anti-Adhesion Products Market based on geography can be further segmented into North America, Europe, Asia-Pacific, South America and Rest of the World. North America (Anti-Adhesion Products Market) held the largest share with 35% of the overall market in 2021. The growth of this region is owing to the surging count of anti-adhesion products introduced by key players like Baxter International in the North American region. Hyaluronic acid is typically utilized as an anti-adhesive barrier.  The soaring count of surgeries with the proliferating possibility of adhesions requiring the application of anti-adhesive products is further propelling the growth of the Anti-Adhesion Products Market in the North American region.

Furthermore, the Asia-Pacific region is estimated to be the region with the fastest CAGR rate over the forecast period 2022-2027. This growth is owing to factors like the expanding medical tourism and the heightening affordability of surgical intervention care in the Asia-Pacific region. The proliferating per-capita healthcare spending and the developing healthcare infrastructure with hyaluronic acid finding application as an anti-adhesive barrier is further fuelling the progress of the Anti-Adhesion Products Market in the Asia-Pacific region.

Anti-Adhesion Products Market Drivers

Surging Applications Of Anti-Adhesive Products Are Projected To Drive The Growth Of the Anti-Adhesion Products Market:

Pharmaceutical Grade Hyaluronic Acid can be utilized as an API (Active Pharmaceutical Ingredient) or excipient for drugs and medical devices in ophthalmic preparations, in-articular injections, anti-adhesive preparations, topical preparations for wound healing and soft tissue filler and more. As per some interesting statistics maintained on the website for Baxter Advanced Surgery, 20-40% of infertility cases are brought about by adhesions and adhesions are the #1 cause of secondary infertility in women. Baxter has developed ADEPT® which has been approved to decrease post-surgical adhesions in patients undergoing gynaecological laparoscopic surgery. Its rare characteristics provide a simple solution leading to superior outcomes in the OR and for the patient on the whole. As a fluid, ADEPT® is administered directly and very quickly to the site by way of a laparoscopic port at the time of surgery thereby demonstrating that it is a “direct and fast-acting application”. It has extensive coverage and optimized resorption. Constituent icodextrin slows the resorption time, while regular liquids would be resorbed much quicker. As per clinical investigations, ADEPT® has a resorption rate of 3-4 days while Lactated Ringer’s Solution has a resorption rate of 24 hours. The surging applications of anti-adhesive products are therefore fuelling the growth of the Anti-Adhesion Products Market during the forecast period 2022-2027.

Proliferating Application Of Biomaterials To Avoid Post-Operative Adhesion Is Expected To Boost The Demand For Anti-Adhesion Products:

Abdominal adhesion happens at the surgical site owing to contact with additional sites at the time of healing and happens in greater than 90% of patients who endure abdominal surgery. Anti-adhesion barriers are mostly developed by utilizing biomaterials. Numerous investigations have used different biomaterials and technologies to develop anti-adhesion barriers. These anti-adhesion biomaterials have superior biocompatibility and biodegradability and can be categorized as either natural or synthetic polymers. Natural polymers are extracted from natural materials and animals (inclusive of humans) and display superior biocompatibility. Gelatin and polysaccharide-based polymers like alginate and hyaluronic acid (HA) are typically utilized as anti-adhesion barriers. Hyaluronic acid has been extensively utilized in cosmetics and pharmaceuticals. HA has a good swelling ability and biocompatibility. Additionally, utilizing HA is beneficial owing to its mechanical characteristics being regulated by way of cross-linking reactions. Synthetic polymers that can be used in the body are typically biocompatible and need to be biodegradable Classic biodegradable synthetic polymers, the polyester-based polymers, involve polylactic acid (PLA), polyglycolic acid (PGA), and poly-caprolactone (PCL). The proliferating application of biomaterials to avoid post-operative adhesion is therefore driving the growth of the Anti-Adhesion Products Market during the forecast period 2022-2027.

Anti-Adhesion Products Market Challenges

Disadvantages Of Biomaterials Used For Developing Anti-Adhesion Barriers Are Hampering The Growth Of The Anti-Adhesion Products Market:

As per statistics maintained on the website for Baxter Advanced Surgery, 34.5% of patients are re-admitted owing to adhesions. Disadvantages of anti-adhesion barriers are associated with the limitations of the biomaterials utilized. Anti-adhesion biomaterials are of two different kinds namely natural and synthetic polymers. The limitation of natural polymers is that it is challenging to keep them up in the body for an expanded duration owing to their poor physical characteristics. Presently, there are nil products that can entirely avoid tissue attachment at surgical sites. Therefore, numerous investigations have been conducted to conquer the limitations of existing anti-adhesion barriers and to establish novel efficient anti-adhesion barriers. Non-fibrous films are acquired by way of electrospinning. Electrospinning can be utilized for numerous polymers, however, toxic solvents are at times utilized, symbolizing a limitation. These issues are thus hampering the growth of the Anti-Adhesion Products Market.

Anti-Adhesion Products Industry Outlook:

Product launches, collaborations, mergers and acquisitions, partnerships and business expansions are key strategies adopted by players in the Anti-Adhesion Products Market. Key companies of this market are:

  1. Baxter International
  2. Genzyme Corporation
  3. Johnson & Johnson
  4. MAST Biosurgery AG
  5. WL Gore
  6. Anika Therapeutics, Inc.
  7. Angiotech Pharmaceuticals, Inc.
  8. LifeCell Corporation (Allergan)
  9. Sanofi SA
  10. FzioMed, Inc.

Recent Developments

In September 2021, Baxter planned to gain Hillrom, extending connected care and medical innovation worldwide. The transaction is valued at $156.00 per Hillrom Share for an All-Cash Purchase Price of $10.5 Billion. Hillrom brings a great complementary product portfolio and innovation pipeline that will allow Baxter to offer a broader assortment of medical products and services to patients and clinicians across the care continuum and across the world, expediting the distribution of healthcare that is patient- and customer-centred and intent on enhancing clinical outcomes.
In January 2021, Sanofi and Kymab, a clinical-stage biopharmaceutical company establishing completely human monoclonal antibodies with a target on immune-mediated ailments and immuno-oncology therapeutics, have recorded an agreement under which Sanofi will gain Kymab for an upfront payment of nearly $1.1 billion and up to $350 million upon accomplishment of some milestones. The transaction will lead to Sanofi having complete global rights to KY1005, a completely human monoclonal antibody that has a novel mechanism of action. KY1005 binds to OX40-Ligand and has the possibility to treat an extensive assortment of immune-mediated ailments and inflammatory disorders.
In February 2020, Baxter International Inc. finished its formerly declared gain of Seprafilm Adhesion Barrier and associated assets from Sanofi for $350 million. The Seprafilm product family, which is utilized as an addition to decreasing the occurrence, extent and severity of adhesions in some pelvic and abdominal surgeries, presently has a global commercial presence in the U.S., Japan, China, South Korea and France, amidst additional countries. Seprafilm has been more greatly assessed than any other adhesion barrier and has been found to considerably decrease the incidence, extent, and severity of adhesions following abdominopelvic surgery.

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1. Anti-Adhesion Products Market Overview
    1.1 Definitions and Scope
2. Anti-Adhesion Products Market - Executive Summary
3. Anti-Adhesion Products Market – Market Landscape
    3.1 Company Benchmarking- Key Companies
    3.2 Key Company Financial Analysis
    3.3 Market Share Analysis
    3.4 Patent Analysis
    3.5 Pricing Analysis (Comparison of General Price Offerings in the Market)
4. Anti-Adhesion Products Market – Startup Company Scenario (Premium)
    4.1 Investment
    4.2 Revenue
    4.3 Venture Capital and Funding Scenario
5. Anti-Adhesion Products Market – Industry Market Entry Scenario Premium (Premium)
    5.1 Regulatory Scenario
    5.2 New Business and Ease of Doing business index
    5.3 Case Studies of Successful Ventures
6. Anti-Adhesion Products Market - Market Forces
    6.1 Market Drivers
    6.2 Market Constraints
    6.3 Porters five force model
        6.3.1 Bargaining power of suppliers
        6.3.2 Bargaining powers of customers
        6.3.3 Threat of new entrants
        6.3.4 Rivalry among existing players
        6.3.5 Threat of substitutes
7. Anti-Adhesion Products Market – By Strategic Analysis
    7.1 Value Chain Analysis
    7.2 Opportunities Analysis
    7.3 Market Life Cycle Analysis
8. Anti-Adhesion Products Market – By Product Type (Market Size –$Million/$Billion) 
    8.1 ADEPT
    8.2 SEPRAFILM 
    8.3 INTERCEED 
9. Anti-Adhesion Products Market - By Type Of Surgery (Market Size –$Million/$Billion) 
    9.1 Abdominal Surgery
    9.2 Gynaecological Surgery
    9.3 Cardiovascular Surgery
    9.4 Orthopaedic Surgery
    9.5 Others
10. Anti-Adhesion Products Market - By Geography (Market Size -$Million/Billion)
    10.1 North America
        10.1.1 U.S
        10.1.2 Canada
        10.1.3 Mexico
    10.2 Europe
        10.2.1 Germany
        10.2.2 France
        10.2.3 UK
        10.2.4 Italy
        10.2.5 Spain
        10.2.6 Russia
        10.2.7 Rest of Europe
    10.3 Asia-Pacific
        10.3.1 China
        10.3.2 Japan
        10.3.3 South Korea
        10.3.4 India
        10.3.5 Australia & New Zealand
        10.3.6 Rest of Asia-Pacific
    10.4 South America
        10.4.1 Brazil
        10.4.2 Argentina
        10.4.3 Chile
        10.4.4 Colombia
        10.4.5 Rest of South America
    10.5 Rest Of The World
        10.5.1 Middle East
        10.5.2 Africa
11. Anti-Adhesion Products Market - Market Entropy
    11.1 New product launches
    11.2 M&A's, collaborations, JVs and partnerships
12. Anti-Adhesion Products Market – Industry Competition Landscape (Premium)
    12.1 Market Share Analysis
        12.1.1 Global Market Share – Key Companies
        12.1.2 Market Share by Region – Key Companies
        12.1.3 Market Share by Countries – Key Companies
    12.2 Competition Matrix
    12.3 Best Practices for Companies
13. Anti-Adhesion Products Market – Key Company List by Country Premium (Premium)
14. Anti-Adhesion Products Market - Company Analysis
    14.1 Company 1
    14.2 Company 2
    14.3 Company 3
    14.4 Company 4
    14.5 Company 5
    14.6 Company 6
    14.7 Company 7
    14.8 Company 8
    14.9 Company 9
    14.10 Company 10
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